Experience
2021-... |
PhD Student ComBi group @ Laboratory of Digital Sciences in Nantes (LS2N) & Nantes University, Nantes, France Logic programs to infer computational models of human embryonic development Under the supervision of Jérémie Bourdon (LS2N), Carito Guziowloski (LS2N) and Laurent David (CR2TI). The advent of new single-cell sequencing technologies now allows for a detailed and in-depth analysis of the gene regulatory mechanisms involved in human embryonic development. This advancement opens new perspectives in the complex and limited study of embryonic development. This thesis focuses on the computational modeling of development to better understand the gene regulatory mechanisms involved. To this end, we present SCIBORG, a method that infers Boolean networks modeling the stages of development of interest. By combining gene interactions from prior knowledge with observed gene expression in embryonic cells, Boolean models are learned, indicating the mechanisms involved in the studied developmental stages. We applied our method to two developmental stages of the trophectoderm and discovered distinct regulatory mechanisms in our models. Overall, this thesis proposes a method for modeling the regulatory mechanisms involved in a cell differentiation process, providing a valuable tool for studying human embryonic development. |
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2021 (6 months) |
Research intern Pleiade group @ Inria, Bordeaux, France Seed detection in metabolic networks Under the supervision of Clémence Frioux. |
2020 (4 months) |
Bioinformatics technician University Hospital of Bordeaux, Bordeaux, France Technician in the Bioinformatics unit of the Biology and Pathology Pole of the Bordeaux University Hospital. |
2020 (4 months) |
Research intern Translational Research in Gene Therapy (TaRGet), Nantes, France Implementation of an NGS library preparation protocol without DNA amplification step (PCR-free protocol) Under the supervision of Émilie Lecomte. Implementation of a PCR-free protocol to prepare DNAs for Illumina sequencing. |
Education
2021-present |
PhD in Computer Science Nantes University, France Specialization Computational Biology |
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2019-2021 |
Master in Computational Biology University of Bordeaux, France Specialization Computational Biology |
2018-2019 |
Bachelor in Computational Biology University of Évry, France Third year of Life Sciences Bachelor specialization Biology and Computer Science |
2016-2018 |
DUT Biological Engineering option Computational Biology University of Clermont Auvergne, Aurillac, France Equivalent of 2 first years of a Bachelor |